CBD Overview

Nanochannel delivery system for CBD: Sustained low level plasma levels without liver toxicity

Cannabidiol (CBD) is a plant-derived cannabinoid found in marijuana and hemp that has been intensely investigated for its putative anti-inflammatory, anxiolytic and/or analgesic effects. Since all these conditions require long-term treatment, sustained release formulations are being investigated.…
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Cannabinoids Block Cellular Entry of SARS-CoV-2 and the Emerging Variants

As a complement to vaccines, small-molecule therapeutic agents are needed to treat or prevent infections by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and its variants, which cause COVID-19. Affinity selection–mass spectrometry was used for the discovery of botanical ligands to the…
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Pharmaceutical oils for Cannabinoid drug products from ADM-SIO

Medicinal Cannabinoids There are currently more than 150 cannabinoid-based products under development in the world. The first US FDA approved product Epidiolex®, isolated from the cannabis plant and indicated for severe forms of epilepsy is formulated with Sesame oil. Other approved products like…
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Development of Water-Soluble Electrospun Fibers for the Oral Delivery of Cannabinoids

Cannabidiol (CBD) and cannabigerol (CBG) are two active pharmaceutical ingredients, derived from cannabis plant. In the present study, CBD and CBG were formulated with polyvinyl(pyrrolidone) (PVP) and Eudragit L-100, using electrohydrodynamic atomization (electrospinning). The produced fibers…
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Hemp in tablets or capsules – Excipients for CBD

Hemp products are mostly sold in liquid form. Companies who are trying to change this and offer solid dose products have to face different challenges. The challenges depend on their choice of solid dosage form (tablets or capsules), technical requirements, their marketing strategy (color, legal…
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Topical Delivery of Cannabinoids

Providing texture and stability A short video to explain how Gattefossé all-in-one emulsifiers help simplify topical formulations and enable to obtain a wide range of sensorial textures Tefose® 63: widely used oil-in-water emulsifier Gelot™ 64: oil-in-water emulsifier, preferred for high…
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Pharmacokinetic Investigation of Synthetic Cannabidiol Oral Formulations in Healthy Volunteers

Recent advances in the research of medicinal cannabis has placed the non-intoxicating cannabinoid cannabidiol (CBD) at the front of many investigations. The reasons behind this popularity is the compound’s therapeutic properties, alongside a safe profile of administration lacking addictive…
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Full-Spectrum Cannabis Extract Microdepots Support Controlled Release of Multiple Phytocannabinoids…

The therapeutic effect of the Cannabis plant largely depends on the presence and specific ratio of a spectrum of phytocannabinoids. While prescription of medicinal Cannabis for various conditions constantly grows, its consumption is mostly limited to oral or respiratory pathways, impeding its…
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Is cannabidiol a scheduled controlled substance? Origin makes the difference

Cannabidiol (CBD) is the main cannabinoid naturally occurring in hemp. It has recently attracted the attention of the scientific community because of its numerous pharmacological activities. However, its legal status changes depending on whether it is chemically synthesized or extracted from the…
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MEDICINAL CANNABIS AND THE GACP/GMP JUNGLE

Medicinal Cannabis can support various treatments in reducing side effects and symptoms, such as nausea and pain. Medicinal Cannabis, however, has to comply to GMP requirements as any medicinal substance or product has. Navigate the requirements together with Avanti Europe. THE RESTRICTIONS AROUND…
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